Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency

SC Kim, SS Sekhon, WR Shin, G Ahn, BK Cho… - Molecular & cellular …, 2022 - Springer
Background mRNA vaccines hold great potential as therapeutic techniques against viral
infections due to their efficacy, safety, and large-scale production. mRNA vaccines offer …

mRNA vaccine: a potential therapeutic strategy

Y Wang, Z Zhang, J Luo, X Han, Y Wei, X Wei - Molecular cancer, 2021 - Springer
Abstract mRNA vaccines have tremendous potential to fight against cancer and viral
diseases due to superiorities in safety, efficacy and industrial production. In recent decades …

Smart polymeric nanoparticles in cancer immunotherapy

Z Yu, X Shen, H Yu, H Tu, C Chittasupho, Y Zhao - Pharmaceutics, 2023 - mdpi.com
Cancer develops with unexpected mutations and causes death in many patients. Among the
different cancer treatment strategies, immunotherapy is promising with the benefits of high …

Recent advances and innovations in the preparation and purification of in Vitro-Transcribed-mRNA-Based molecules

J Zhang, Y Liu, C Li, Q Xiao, D Zhang, Y Chen… - Pharmaceutics, 2023 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic poses a disruptive impact on public
health and the global economy. Fortunately, the development of COVID-19 vaccines based …

Vaccine design against chagas disease focused on the use of nucleic acids

E Maldonado, S Morales-Pison, F Urbina, A Solari - Vaccines, 2022 - mdpi.com
Chagas disease is caused by the protozoan Trypanosoma cruzi and is endemic to Central
and South America. However, it has spread around the world and affects several million …

Initiator-directed transcription: Fission yeast nmtl initiator directs preinitiation complex formation and transcriptional initiation

DA Rojas, F Urbina, L Valenzuela-Pérez, L Leiva… - Genes, 2022 - mdpi.com
The initiator element is a core promoter element encompassing the transcription start site,
which is found in yeast, Drosophila, and human promoters. This element is observed in …

[PDF][PDF] Produção científica latino-americana sobre produtos à base de nanotecnologia para o enfrentamento da COVID-19: uma revisão de escopo

DM Mota, PJG Ferreira, FT Primo - Vigilância Sanitária em Debate …, 2023 - redalyc.org
Introdução: A produção científica tem experimentado um aumento sem precedentes com a
pandemia de COVID-19 em um curto espaço de tempo. Objetivo: Identificar e caracterizar a …

[PDF][PDF] Vaccine Design against Chagas Disease Focused on the Use of Nucleic Acids. Vaccines 2022, 10, 587

E Maldonado, S Morales-Pison, F Urbina, A Solari - 2022 - pdfs.semanticscholar.org
Chagas disease is caused by the protozoan Trypanosoma cruzi and is endemic to Central
and South America. However, it has spread around the world and affects several million …

Vaccine design against chagas disease focused on the use of nucleic acids

E Maldonado Maldonado, S Morales Pisón, F Urbina… - 2022 - repositorio.uchile.cl
Chagas disease is caused by the protozoan Trypanosoma cruzi and is endemic to Central
and South America. However, it has spread around the world and affects several million …

The Current State of Non-Viral Vector–Based mRNA Medicine Using Various Nanotechnology Applications

K Patel, P Dasika, YV Pathak - Gene Delivery Systems, 2022 - taylorfrancis.com
Ribonucleic acid (RNA) is a biological macromolecule that is a cornerstone in carrying out
thousands of biological processes in an organism. RNA takes up the roles of handling …