Ketogenic diet for human diseases: the underlying mechanisms and potential for clinical implementations

H Zhu, D Bi, Y Zhang, C Kong, J Du, X Wu… - Signal transduction and …, 2022 - nature.com
The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

[HTML][HTML] Ketogenic diet in the treatment of cancer–where do we stand?

DD Weber, S Aminzadeh-Gohari, J Tulipan… - Molecular …, 2020 - Elsevier
Background Cancer is one of the greatest public health challenges worldwide, and we still
lack complementary approaches to significantly enhance the efficacy of standard anticancer …

Ketogenic diets for drug‐resistant epilepsy

KJ Martin-McGill, R Bresnahan… - Cochrane Database …, 2020 - cochranelibrary.com
Ketogenic diets for drug‐resistant epilepsy - Martin-McGill, KJ - 2020 | Cochrane Library Skip
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The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

EG Neal, H Chaffe, RH Schwartz, MS Lawson… - The Lancet …, 2008 - thelancet.com
Background The ketogenic diet has been widely and successfully used to treat children with
drug-resistant epilepsy since the 1920s. The aim of this study was to test the efficacy of the …

Emerging role of hepatic ketogenesis in fatty liver disease

RGR Mooli, SK Ramakrishnan - Frontiers in Physiology, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver diseases, arise
from non-alcoholic fatty liver (NAFL) characterized by excessive fat accumulation as …

Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet

KJ Bough, J Wetherington, B Hassel… - Annals of Neurology …, 2006 - Wiley Online Library
Objective The full anticonvulsant effect of the ketogenic diet (KD) can require weeks to
develop in rats, suggesting that altered gene expression is involved. The KD typically is …

Anticonvulsant mechanisms of the ketogenic diet

KJ Bough, JM Rho - Epilepsia, 2007 - Wiley Online Library
The ketogenic diet (KD) is a broadly effective treatment for medically refractory epilepsy.
Despite nearly a century of use, the mechanisms underlying its clinical efficacy remain …

A randomized trial of classical and medium‐chain triglyceride ketogenic diets in the treatment of childhood epilepsy

EG Neal, H Chaffe, RH Schwartz, MS Lawson… - …, 2009 - Wiley Online Library
Purpose: To conduct the first randomized trial on classical and medium‐chain triglyceride
(MCT) versions of the ketogenic diet, examining efficacy and tolerability after 3, 6, and 12 …

Ketogenic diets: from cancer to mitochondrial diseases and beyond

AF Branco, A Ferreira, RF Simões… - European journal of …, 2016 - Wiley Online Library
Background The employment of dietary strategies such as ketogenic diets, which force cells
to alter their energy source, has shown efficacy in the treatment of several diseases …

Impact of dietary fats on brain functions

R Chianese, R Coccurello, A Viggiano… - Current …, 2018 - ingentaconnect.com
Background: Adequate dietary intake and nutritional status have important effects on brain
functions and on brain health. Energy intake and specific nutrients excess or deficiency from …