Background Deleterious germline variants in ATM and CHEK2 have been associated with a
moderately increased risk of breast cancer. Risks for other cancers remain unclear. Methods …

Multigene panel testing now allows efficient testing of many cancer susceptibility genes
leading to a larger number of mutation carriers being identified. They need to be counseled …

Breast cancer (BC) is an increasing public health issue worldwide. BC incidence and
mortality rates are rising in transitioning countries in Africa, with the most rapid increase …

Multi-gene panel testing allows efficient detection of pathogenic variants in cancer
susceptibility genes including moderate-risk genes such as ATM and PALB2. A growing …

Purpose ATM germline pathogenic variants (GPVs) are associated with a moderately
increased risk of female breast cancer, pancreatic cancer, and prostate cancer. Resources …

Epidemiologic data on insecticide exposures and breast cancer risk are inconclusive and
mostly from high-income countries. Using data from 1071 invasive pathologically confirmed …

Background The two major causes of cancer-related deaths among women in Ghana are
breast cancer (BC) and cervical cancer (CC). These types of cancers typically do not show …

Concurrent testing of numerous genes for hereditary breast cancer (BC) is available but can
result in management difficulties. We evaluated use of an expanded BC gene panel in …

Objectives Absolute risk models estimate an individual's future disease risk over a specified
time interval. Applications utilizing server-side risk tooling, the R-based iCARE (R-iCARE), to …

Purpose Breast cancer is a major cause of cancer-related mortality among African women.
The adoption of molecular genomic technologies in the management of cancer cases is …