TRH is a tripeptide amide that functions as a neurotransmitter but also serves as a
neurohormone that has a critical role in the central regulation of the hypothalamic-pituitary …

The onset of puberty and the female ovulatory cycle are important developmental milestones
of the reproductive system. These processes are controlled by a tightly organized network of …

Anti-Müllerian hormone (AMH) plays crucial roles in sexual differentiation and gonadal
functions. However, the possible extragonadal effects of AMH on the hypothalamic–pituitary …

Emerging evidence suggests that new cells, including neurons, can be generated within the
adult hypothalamus, suggesting the existence of a local neural stem/progenitor cell niche …

Background Polycystic ovary syndrome (PCOS) is the most common reproductive-endocrine
disorder affecting between 5 and 18% of women worldwide. An elevated frequency of …

Non‐technical summary The hypothalamus contains key neural circuits involved in the
control of feeding and energy balance. Stimulated by the inexorable rise of obesity, there …

Natural fluctuations in physiological conditions require adaptive responses involving rapid
and reversible structural and functional changes in the hypothalamic neuroendocrine …

In the last years there has been a considerable advance in the knowledge on the regulation
of astrocytes by sex steroids under physiological and pathological conditions. By the …

Reproductive competence in mammals depends on the projection of gonadotropin-
releasing hormone (GnRH) neurons to the hypothalamic median eminence (ME) and the …

Persistent free-running circannual (approximately year-long) rhythms have evolved in
animals to regulate hormone cycles, drive metabolic rhythms (including hibernation), and …