The role of m6A RNA methylation in human cancer

XY Chen, J Zhang, JS Zhu - Molecular cancer, 2019 - Springer
Abstract N 6-methyladenosine (m 6 A) is identified as the most common, abundant and
conserved internal transcriptional modification, especially within eukaryotic messenger …

Roles of RNA methylation by means of N6-methyladenosine (m6A) in human cancers

S Wang, C Sun, J Li, E Zhang, Z Ma, W Xu, H Li, M Qiu… - Cancer letters, 2017 - Elsevier
Reversible methylation by means of N6-methyladenosine (m 6 A) is the most prevalent
internal modification in mammalian mRNA. This RNA chemical mark is created by proteins …

Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds

P Hou, Y Li, X Zhang, C Liu, J Guan, H Li, T Zhao, J Ye… - Science, 2013 - science.org
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell
resource, with potential for studying disease and use in regenerative medicine. However …

Regulatory Role of N6‐methyladenosine (m6A) Methylation in RNA Processing and Human Diseases

W Wei, X Ji, X Guo, S Ji - Journal of Cellular Biochemistry, 2017 - Wiley Online Library
ABSTRACT N6‐methyladenosine (m6A) modification is an abundant and conservative RNA
modification in bacterial and eukaryotic cells. m6A modification mainly occurs in the 3 …

Suppression of EZH2 prevents the shift of osteoporotic MSC fate to adipocyte and enhances bone formation during osteoporosis

H Jing, L Liao, Y An, X Su, S Liu, Y Shuai, X Zhang… - Molecular Therapy, 2016 - cell.com
During osteoporosis, the shift of mesenchymal stem cell (MSC) lineage commitment to
adipocyte leads to the imbalance between bone mass and fat, which increases the risk of …

EZH2 abnormalities in lymphoid malignancies: underlying mechanisms and therapeutic implications

B Li, WJ Chng - Journal of Hematology & Oncology, 2019 - Springer
EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which along
with other PRC2 components mediates gene expression suppression via the methylation of …

Epitranscriptomic (N6-methyladenosine) modification of viral RNA and virus-host interactions

H Imam, GW Kim, A Siddiqui - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
N6-methyladenosine (m6A) is the most prevalent and internal modification of eukaryotic
mRNA. Multiple m6A methylation sites have been identified in the viral RNA genome and …

Imidazopyridines as a source of biological activity and their pharmacological potentials—infrared and Raman spectroscopic evidence of their content in …

L Dymińska - Bioorganic & Medicinal Chemistry, 2015 - Elsevier
Derivatives of imidazopyridine are used in medicinal chemistry due to their biological and
pharmaceutical properties. This review article presents imidazopyridine pharmacological …

Viral epitranscriptomics

EM Kennedy, DG Courtney, K Tsai… - Journal of virology, 2017 - Am Soc Microbiol
Although it has been known for over 40 years that eukaryotic mRNAs bear internal base
modifications, it is only in the last 5 years that the importance of these modifications has …

Synthesis of cyclopentitols by ring-closing approaches

VB Kurteva, CAM Afonso - Chemical reviews, 2009 - ACS Publications
Considerable effort has been devoted in the past decades to the development of new
methods for the construction of five-membered carbocycles, since they play a fundamental …