Phytochemicals in cancer treatment: From preclinical studies to clinical practice

AS Choudhari, PC Mandave, M Deshpande… - Frontiers in …, 2020 - frontiersin.org
Cancer is a severe health problem that continues to be a leading cause of death worldwide.
Increasing knowledge of the molecular mechanisms underlying cancer progression has led …

Hepatoprotective effect of plant polysaccharides from natural resources: A review of the mechanisms and structure-activity relationship

J Qu, P Huang, L Zhang, Y Qiu, H Qi, A Leng… - International journal of …, 2020 - Elsevier
Liver injury is a common pathological process, which can result in fatty liver, cirrhosis,
fibrosis and even cancer. Polysaccharides isolated from plants have been regarded as an …

[HTML][HTML] Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

J Yang, C Pi, G Wang - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Apigenin is a dietary flavonoid with known antioxidant and antitumor effects against several
types of cancers by promoting cell death and inducing cell cycle arrest. Apigenin also …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Stigmasterol simultaneously induces apoptosis and protective autophagy by inhibiting Akt/mTOR pathway in gastric cancer cells

H Zhao, X Zhang, M Wang, Y Lin, S Zhou - Frontiers in oncology, 2021 - frontiersin.org
Background Stigmasterol (SS) has been proven to possess potential anticancer activities in
several cancer cell lines, but its molecular mechanism is still unknown. Thus, we …

Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives

S Patra, SR Mishra, BP Behera, KK Mahapatra… - Seminars in cancer …, 2022 - Elsevier
Autophagy is an intracellular catabolic self-cannibalism that eliminates dysfunctional
cytoplasmic cargos by the fusion of cargo-containing autophagosomes with lysosomes to …

Role of licochalcone A in potential pharmacological therapy: a review

MT Li, L Xie, HM Jiang, Q Huang, RS Tong… - Frontiers in …, 2022 - frontiersin.org
Licochalcone A (LA), a useful and valuable flavonoid, is isolated from Glycyrrhiza uralensis
Fisch. ex DC. and widely used clinically in traditional Chinese medicine. We systematically …

Protective effects of licochalcone A ameliorates obesity and non-alcoholic fatty liver disease via promotion of the Sirt-1/AMPK pathway in mice fed a high-fat diet

CJ Liou, YK Lee, NC Ting, YL Chen, SC Shen, SJ Wu… - Cells, 2019 - mdpi.com
Licochalcone A is a chalcone isolated from Glycyrrhiza uralensis. It showed anti-tumor and
anti-inflammatory properties in mice with acute lung injuries and regulated lipid metabolism …

[HTML][HTML] Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway

F Liu, S Gao, Y Yang, X Zhao, Y Fan… - Oncology …, 2018 - spandidos-publications.com
Curcumin is known to exhibit anticancer effects on various cancers with selective cytotoxicity
in tumor cells. In the present study, the effects of curcumin‑induced multiple PCDs on human …

Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer

J Sophia, J Kowshik, A Dwivedi, SK Bhutia… - Cell death & …, 2018 - nature.com
Of late, nimbolide, a limonoid from the neem tree (Azadirachta indica) has gained increasing
research attention owing to its potent antiproliferative and apoptosis-inducing effects. The …