Candida albicans is a common fungus of the human microbiota. While generally a harmless
commensal in healthy individuals, several factors can lead to its overgrowth and cause a …

Highlights•Biofilm formation is a major contributor to pathogenesis during Candida
infection.•C. albicans biofilm formation is a multi-step, highly regulated process.•Cells in …

Like other microorganisms, free-living Candida albicans is mainly present in a three-
dimensional multicellular structure, which is called a biofilm, rather than in a planktonic form …

Candidemia and invasive candidiasis are the most common healthcare-associated invasive
fungal infections, with a crude mortality rate of 25–50%. Candida albicans remains the most …

Fungal diseases are severe and have very high morbidity as well as up to 60% mortality for
patients diagnosed with invasive fungal infection. In this review, in vitro and in vivo studies …

In healthcare settings, Candida spp. cause invasive disease with high mortality. The
overwhelming majority of cases are associated with the use of critically-needed medical …

Objectives Echinocandins are the newest addition of the last decade to the antifungal
armamentarium, which, owing to their unique mechanism of action, selectively target the …

Osteoarticular mycoses are chronic debilitating infections that require extended courses of
antifungal therapy and may warrant expert surgical intervention. As there has been no …

It has been nearly a decade since caspofungin was approved for clinical use as the first
echinocandin class antifungal agent, followed by micafungin and anidulafungin. The …

Only few Candida species, eg, Candida albicans, Candida glabrata, Candida dubliniensis,
and Candida parapsilosis, are successful colonizers of a human host. Under certain …