NAFLD is closely linked with hepatic insulin resistance. Accumulation of hepatic
diacylglycerol activates PKC-ε, impairing insulin receptor activation and insulin-stimulated …

Resistance training (RT) is the only non-pharmacological intervention known to consistently
improve, and therefore offset age-related declines in, skeletal muscle mass, strength, and …

This consensus statement is an update of the 2010 ACSM position stand on exercise and
type 2 diabetes. Since then, a substantial amount of research on select topics in exercise in …

Background Physical activity (PA) breaks in sitting time might attenuate metabolic markers
relevant to the prevention of type 2 diabetes. Objectives The primary aim of this paper was to …

Purpose and methods This review presents established knowledge on the effects of physical
activity (PA) on whole-body insulin sensitivity (SI) and summarises the findings of recent …

Primary aging is the progressive and inevitable process of bodily deterioration during
adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and …

Insulin resistance arises when the nutrient storage pathways evolved to maximize efficient
energy utilization are exposed to chronic energy surplus. Ectopic lipid accumulation in liver …

Background The efficacy of high-intensity interval training for a broad spectrum of cardio-
metabolic health outcomes is not in question. Rather, the effectiveness of this form of …

Normal energy metabolism is characterized by periodic shifts in glucose and fat oxidation,
as the mitochondrial machinery responsible for carbon combustion switches freely between …

We define exercise snacks as isolated≤ 1-min bouts of vigorous exercise performed
periodically throughout the day. We hypothesize that exercise snacks are a feasible, well …