Designing of a next generation multiepitope based vaccine (MEV) against SARS-COV-2: Immunoinformatics and in silico approaches

M Tahir ul Qamar, A Rehman, K Tusleem, UA Ashfaq… - PloS one, 2020 - journals.plos.org
Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
coronavirus 2 (SARS-COV-2) is a significant threat to global health security. Till date, no …

Multiepitope-based subunit vaccine design and evaluation against respiratory syncytial virus using reverse vaccinology approach

M Tahir ul Qamar, Z Shokat, I Muneer, UA Ashfaq… - Vaccines, 2020 - mdpi.com
Respiratory syncytial virus (RSV) is primarily associated with respiratory disorders globally.
Despite the availability of information, there is still no competitive vaccine available for RSV …

Designing a multi-epitope subunit vaccine against VP1 major coat protein of JC polyomavirus

S Kanse, M Khandelwal, RK Pandey, M Khokhar… - Vaccines, 2023 - mdpi.com
The JC polyomavirus virus (JCPyV) affects more than 80% of the human population in their
early life stage. It mainly affects immunocompromised individuals where virus replication in …

Recent advances in the development of virus-like particle-based flavivirus vaccines

N Zhang, C Li, S Jiang, L Du - Vaccines, 2020 - mdpi.com
Flaviviruses include several medically important viruses, such as Zika virus (ZIKV), Dengue
virus (DENV), West Nile virus (WNV) and Japanese encephalitis virus (JEV). They have …

ATP-sensitive inward rectifier potassium channels reveal functional linkage between salivary gland function and blood feeding in the mosquito, Aedes aegypti

Z Li, A Soohoo-Hui, FM O'Hara, DR Swale - Communications biology, 2022 - nature.com
Reducing saliva secretions into the vertebrate host reduces feeding efficacy by most
hematophagous arthropods. However, seminal studies suggested saliva is not a …

Immuno-informatics guided designing of a multi-epitope vaccine against Dengue and Zika

A Bhardwaj, R Sharma, A Grover - Journal of Biomolecular …, 2023 - Taylor & Francis
Dengue and zika are amongst the most prevalent mosquito-borne diseases caused by
closely related members Dengue virus (DENV) and Zika virus (ZIKV), respectively, of the …

The role of Aedes aegypti in inducing/aggravating IgE-mediated allergic airway disease: extensive computational studies for identification of allergenic proteins

MA Kausar, AM Rabie, F Azam, S Anwar… - Journal of …, 2024 - Taylor & Francis
Respiratory allergies have become a major public health concern and affect one-third of the
world's population. Several factors like environmental changes, industrialization, and …

An immunoinformatic approach to universal therapeutic vaccine design against BK virus

V Kesherwani, S Tarang - Vaccine, 2019 - Elsevier
In kidney transplant recipients (KTRs) long-term immunosuppression leads to BK virus
(BKV) reactivation, with an increased incidence of BKV-associated pathologies and allograft …

Effects of Aedes aegypti salivary protein on duck Tembusu virus replication and transmission in salivary glands

C Sri-In, A Thontiravong, LC Bartholomay… - Acta Tropica, 2022 - Elsevier
Duck Tembusu virus (DTMUV) infection is an arthropod-borne viral disease that affects
many poultry species, including ducks, chickens, and geese. Aedes aegypti mosquito is an …

Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes

RP Kozak, K Mondragon-Shem… - PLoS neglected …, 2021 - journals.plos.org
African sleeping sickness is caused by Trypanosoma brucei, a parasite transmitted by the
bite of a tsetse fly. Trypanosome infection induces a severe transcriptional downregulation of …