Leptin is a polypeptide hormone that aids in the regulation of body weight and energy
homeostasis and is linked to a variety of reproductive processes in both animals and …

Much attention has focused on the effects of leptin as a central satiety agent. There is now a
significant amount of evidence that leptin is active in the periphery. This review focuses on …

The insulin-like growth factor (IGF) system is the dominant endocrine regulator of fetal
growth, whereas insulin has a permissive role. Although a role for leptin in fetal growth has …

Leptin is a 16-kDa cytokine secreted in humans primarily but not exclusively by adipose
tissues. Its concentration in blood is usually proportional to body fat mass, but is higher in …

Intrauterine growth restriction (IUGR) is the failure of the fetus to achieve his/her intrinsic
growth potential, due to anatomical and/or functional disorders and diseases in the feto …

Recently, leptin has emerged as a potential candidate responsible for protective effects of fat
on bone tissue. However, it remains difficult to draw a clear picture of leptin effects on bone …

The relationship between in utero fetal growth and fetal leptin concentrations was
investigated between 19 and 41 wk in 40 normal (appropriate for gestational age, AGA) …

Many adult diseases, including type 2 diabetes, hypertension and cardiovascular disease,
are related to low birth weight. The mechanistic basis of this relationship is not known. To …

In adult animals, leptin is an adipose‐derived hormone that is important primarily in the
regulation of energy balance during short‐and long‐term changes in nutritional state …

As an essential function for perpetuation of species, reproduction, including puberty onset, is
sensitive to the size of body energy stores and the metabolic state of the organism …