The superfamily of G protein-coupled receptors (GPCRs) contains immense structural and
functional diversity and mediates a myriad of biological processes upon activation by …

Spontaneous tumors in dogs share several environmental, epidemiologic, biologic, clinical
and molecular features with a wide variety of human cancers, making this companion animal …

Cadherin-6 (CDH6) is aberrantly expressed in cancer and closely associated with tumor
progression. However, the functions of CDH6 in human osteosarcoma and the molecular …

Background Preterm birth remains a leading obstetrical complication because of the
incomplete understanding of its multifaceted etiology. It is known that immune alterations …

Opioid use disorder (OUD) is influenced by genetic and environmental factors. While recent
research suggests epigenetic disturbances in OUD, this is mostly limited to DNA methylation …

Osteosarcoma is a common malignant bone cancer easily to metastasize. Much safer and
more efficient strategies are still needed to suppress osteosarcoma growth and lung …

Background Coordination between osteo-/angiogenesis and the osteoimmune
microenvironment is essential for effective bone repair with biomaterials. As a highly …

Sustained activation of multiple receptor tyrosine kinases (RTKs) simultaneously is vital for
tumorigenesis and progression of osteosarcoma (OS). Gαi proteins recruitment to various …

Aims Magnoflorine is an essential type of alkaloid and possesses anti-tumor activity in
multiple cancers. Recent studies have demonstrated that magnoflorine plays tumor …

Abstract Natriuretic peptide receptor 3 (NPR3), mediates natriuretic peptides degradation,
was reported to act as a tumor suppressor or promoter in some types of cancer. Previous …