Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …

In recent years, there has been a surge in the research and development of novel molecules
as potential therapeutic alternatives to traditional treatments (such as intravenous …

The concept of engineering robust protein scaffolds for novel binding functions emerged 20
years ago, one decade after the advent of recombinant antibody technology. Early examples …

Bile acids are synthesized in the liver, stored in the gallbladder, and secreted into the
duodenum at meals. Apical sodium-dependent bile acid transporter (ASBT), an ileal Na+ …

The MHC class I-related receptor FcRn serves multiple roles ranging from the regulation of
levels of IgG isotype antibodies and albumin throughout the body to the delivery of antigen …

Autoantibodies are increasingly recognized for their pathogenic potential in a growing
number of neurological diseases. While myasthenia gravis represents the prototypic …

Autoantibodies are well known as potentially highly harmful antibodies which attack the host
via binding to self-antigens, thus causing severe associated diseases and symptoms (eg …

Candida auris is a multi-drug-resistant fungal pathogen that can survive outside the host and
can easily spread and colonize the healthcare environment, medical devices, and human …

As an essential modulator of IgG disposition, the neonatal Fc receptor (FcRn) governs the
pharmacokinetics and functions many therapeutic modalities. In this review, we thoroughly …

There is an urgent need for therapeutic interventions for desensitization and antibody-
mediated rejection (AMR) in sensitized patients with preformed or de novo donor-specific …