The menace of obesity to depression and anxiety prevalence

S Fulton, L Décarie-Spain, X Fioramonti… - Trends in Endocrinology …, 2022 - cell.com
The incidence of depression and anxiety is amplified by obesity. Mounting evidence reveals
that the psychiatric consequences of obesity stem from poor diet, inactivity, and visceral …

Comorbid depression in medical diseases

SM Gold, O Köhler-Forsberg, R Moss-Morris… - Nature Reviews …, 2020 - nature.com
Depression is one of the most common comorbidities of many chronic medical diseases
including cancer and cardiovascular, metabolic, inflammatory and neurological disorders …

Depression and obesity: evidence of shared biological mechanisms

Y Milaneschi, WK Simmons, EFC van Rossum… - Molecular …, 2019 - nature.com
Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …

Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts

Y Milaneschi, N Kappelmann, Z Ye, F Lamers… - Molecular …, 2021 - nature.com
We examined whether inflammation is uniformly associated with all depressive and anxiety
symptoms, and whether these associations are potentially causal. Data was from 147,478 …

The genetic basis of major depression

KM Kendall, E Van Assche, TFM Andlauer… - Psychological …, 2021 - cambridge.org
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …

Machine learning in major depression: From classification to treatment outcome prediction

S Gao, VD Calhoun, J Sui - CNS neuroscience & therapeutics, 2018 - Wiley Online Library
Aims Major depression disorder (MDD) is the single greatest cause of disability and
morbidity, and affects about 10% of the population worldwide. Currently, there are no …

Depression heterogeneity and its biological underpinnings: toward immunometabolic depression

Y Milaneschi, F Lamers, M Berk, BWJH Penninx - Biological psychiatry, 2020 - Elsevier
Epidemiological evidence indicates the presence of dysregulated homeostatic biological
pathways in depressed patients, such as increased inflammation and disrupted energy …

Dissecting the association between inflammation, metabolic dysregulation, and specific depressive symptoms: a genetic correlation and 2-sample mendelian …

N Kappelmann, J Arloth, MK Georgakis… - JAMA …, 2021 - jamanetwork.com
Importance Observational studies highlight associations of C-reactive protein (CRP), a
general marker of inflammation, and interleukin 6 (IL-6), a cytokine-stimulating CRP …

High fat diet-induced obesity leads to depressive and anxiety-like behaviors in mice via AMPK/mTOR-mediated autophagy

Y Li, Y Cheng, Y Zhou, H Du, C Zhang, Z Zhao… - Experimental …, 2022 - Elsevier
Depression is one of the most common mental illnesses in modern society. In recent years,
several studies show that there are disturbances in lipid metabolism in depressed patients …

Central and peripheral inflammation link metabolic syndrome and major depressive disorder

KL Chan, F Cathomas, SJ Russo - Physiology, 2019 - journals.physiology.org
Metabolic syndrome and major depression are two of the most common and debilitating
disorders worldwide, occurring with significant rates of comorbidity. Recent studies have …