Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …

Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …

Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions,
via activation of its high affinity receptor, tropomysin related kinase B (TrkB). In addition …

Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results
in motor dysfunction and death, generally from respiratory failure. 90% of ALS cases are …

Synapse loss is an early feature shared by many neurodegenerative diseases, and it
represents the major correlate of cognitive impairment. Recent studies reveal that microglia …

Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). Mutant FUS is
known to confer cytoplasmic gain of function but its effects in the nucleus are less …

Damage to DNA is generally considered to be a harmful process associated with aging and
aging-related disorders such as neurodegenerative diseases that involve the selective …

The onset of amyotrophic lateral sclerosis (ALS) is conventionally considered as
commencing with the recognition of clinical symptoms. We propose that, in common with …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal motor neuron disease.
Diagnosis typically occurs in the fifth decade of life and the disease progresses rapidly …

Amyotrophic lateral sclerosis (ALS) is an aggressive and uniformly fatal degenerative
disease of the motor nervous system. In order to understand underlying disease …