Phylloquinone (vitamin K1) and menaquinones (vitamin K2 family) are essential for post-
translational γ-carboxylation of a small number of proteins, including clotting factors. These …

Vitamin K (VK), a fat-soluble vitamin, is essential for the clotting of blood because of its role
in the production of clotting factors in the liver. Moreover, researchers continue to explore the …

Fat-soluble vitamins (vitamin A, D, E, and K) assume a pivotal role in maintaining human
homeostasis by virtue of their enzymatic functions. The daily inclusion of these vitamins is …

Cancer encompasses a group of pathologies with common characteristics, high incidence,
and prevalence in all countries. Although there are treatments available for this disease …

The most important dose-limiting factor of the anthracycline idarubicin is the high risk of
cardiotoxicity, in which the secondary alcohol metabolite idarubicinol plays an important …

Several studies have investigated the relationship between vitamin D (VD) and its receptors
(VDR) and the risk of cervical cancer. However, the underlying mechanisms that underpin …

Pancreatic ductal adenocarcinoma (PDAC) represents a highly aggressive malignancy with
a lack of reliable diagnostic biomarkers. Protein induced by vitamin K absence (PIVKA-II) is …

Vitamin K derivatives such as menadione (MD) have been recognized as promising redox-
modulating and chemosensitizing agents for anticancer therapy, however, their cellular …

Background Abelson (ABL) tyrosine kinase inhibitors (TKIs) are effective against chronic
myeloid leukemia (CML); however, many patients develop resistance during ABL TKI …

Thiadiazine‐based components have gained the attention as they afford significant
intervention for cancer therapy. We aimed at assessing the in vivo antitumor activity of …