A global accounting of medically significant scorpions: Epidemiology, major toxins, and comparative resources in harmless counterparts
Scorpions are an ancient and diverse venomous lineage, with over 2200 currently
recognized species. Only a small fraction of scorpion species are considered harmful to …
recognized species. Only a small fraction of scorpion species are considered harmful to …
Voltage-gated sodium channel modulation by scorpion α-toxins
Voltage-gated Na+ channels are integral membrane proteins that function as a gateway for
a selective permeation of sodium ions across biological membranes. In this way, they are …
a selective permeation of sodium ions across biological membranes. In this way, they are …
Sodium channels and pain: From toxins to therapies
FC Cardoso, RJ Lewis - British journal of pharmacology, 2018 - Wiley Online Library
Voltage‐gated sodium channels (NaV channels) are essential for the initiation and
propagation of action potentials that critically influence our ability to respond to a diverse …
propagation of action potentials that critically influence our ability to respond to a diverse …
Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens
Spider venoms are a rich source of ion channel modulators with therapeutic potential. Given
the analgesic potential of subtype-selective inhibitors of voltage-gated sodium (NaV) …
the analgesic potential of subtype-selective inhibitors of voltage-gated sodium (NaV) …
[HTML][HTML] Epidemiological review of scorpion envenomation in Iran
This epidemiological review was carried out to display the magnitude and the geographic
distribution of scorpion envenomation in Iran with focus on the southwestern region of Iran …
distribution of scorpion envenomation in Iran with focus on the southwestern region of Iran …
A review of epidemiological, clinical and in vitro physiological studies of envenomation by the scorpion Hemiscorpius lepturus (Hemiscorpiidae) in Iran
Many of the published accounts of envenomation by Hemiscorpius lepturus (H. lepturus) are
in a form that makes it difficult for non Farsi readers to access. The purpose of this review is …
in a form that makes it difficult for non Farsi readers to access. The purpose of this review is …
The differential preference of scorpion α-toxins for insect or mammalian sodium channels: implications for improved insect control
Receptor site-3 on voltage-gated sodium channels is targeted by a variety of structurally
distinct toxins from scorpions, sea anemones, and spiders whose typical action is the …
distinct toxins from scorpions, sea anemones, and spiders whose typical action is the …
Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells
The human neuroblastoma cell line SH-SY5Y is a potentially useful model for the
identification and characterisation of Nav modulators, but little is known about the …
identification and characterisation of Nav modulators, but little is known about the …
Potent modulation of the voltage-gated sodium channel Nav1. 7 by OD1, a toxin from the scorpion Odonthobuthus doriae
Voltage-gated sodium channels are essential for the propagation of action potentials in
nociceptive neurons. Nav1. 7 is found in peripheral sensory and sympathetic neurons and …
nociceptive neurons. Nav1. 7 is found in peripheral sensory and sympathetic neurons and …
Nanobodies as novel therapeutic agents in envenomation
E Alirahimi, F Kazemi-Lomedasht… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Background An effective therapy against envenoming should be a priority in view of the high
number scorpion stings and snakebites. Serum therapy is still widely applied to treat the …
number scorpion stings and snakebites. Serum therapy is still widely applied to treat the …