N-linked protein glycosylation in the endoplasmic reticulum (ER) is a conserved two phase
process in eukaryotic cells. It involves the assembly of an oligosaccharide on a lipid carrier …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

The attachment of glycans to asparagine residues of proteins is an abundant and highly
conserved essential modification in eukaryotes. The N-glycosylation process includes two …

Pioneering electron microscopy studies defined two primary populations of ribosomes in
eukaryotic cells: one freely dispersed through the cytoplasm and the other bound to the …

Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces
cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We …

The processing of N-linked glycans determines secretory protein homeostasis in the
eukaryotic cell. Folding and degradation of glycoproteins in the endoplasmic reticulum (ER) …

Protein translocation into the endoplasmic reticulum (ER) is the first and decisive step in the
biogenesis of most extracellular and many soluble organelle proteins in eukaryotic cells. It is …

Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

Protein N-glycosylation is one of the major post-translational modifications in eukaryotic
cells. In lower unicellular eukaryotes, the known functions of N-glycans are predominantly in …

Oligosaccharyltransferase (OST) is an essential membrane protein complex in the
endoplasmic reticulum, where it transfers an oligosaccharide from a dolichol-pyrophosphate …