Partner and localizer of BRCA2 (PALB2) was originally identified as a BRCA2-interacting
protein that is crucial for key BRCA2 genome caretaker functions. It subsequently became …

To date, five moderate-risk breast cancer susceptibility genes have been convincingly
identified: CHEK2, ATM, BRIP1, PALB2, and NBS1. Moderate-risk breast cancer alleles …

Inherited mutations in the BRCA2-interacting protein PALB2 are known to be associated
with increased risks of developing breast cancer. To evaluate the contribution of PALB2 to …

Background Mutations in PALB2 predispose to breast cancer, but the effect on prognosis of
carrying a PALB2 mutation has not been ascertained. We aimed to estimate the odds ratio …

Introduction As a group, women who carry germline mutations in partner and localizer of
breast cancer 2 susceptibility protein (PALB2) are at increased risk of breast cancer. Little is …

Background Partner and localizer BRCA2 (PALB2) is a breast cancer predisposition gene,
but the clinical relevance of PALB2 germline mutations in Chinese patients with breast …

Breast cancer is the most common cancer among women, accounting for about 30% of all
cancers. In contrast, breast cancer is a rare disease in men, accounting for less than 1% of …

Since germline mutations in the PALB2 (Partner and Localizer of BRCA2) gene have been
identified as breast cancer (BC) susceptibility alleles, the geographical spread and risks …

It has been demonstrated that monoallelic PALB2 (Partner and Localizer of BRCA2) gene
mutations predispose to familial breast cancer. Some of the families reported with germline …

Mutations of the PALB2 tumor suppressor gene in humans are associated with hereditary
predisposition to breast and also some other cancers. In the present study, we have …