Apathy and anhedonia are common syndromes of motivation that are associated with a wide
range of brain disorders and have no established therapies. Research using animal models …

Parkinson's Disease (PD) is a neurodegenerative disorder that affects dopaminergic
neurons in the mesencephalic substantia nigra, causing a progressive clinical course …

Converging lines of evidence suggest that the pathophysiology of pain is mediated to a
substantial degree via allostatic neuroadaptations in reward-and stress-related brain …

Importance Anhedonia, a reduced capacity for pleasure, is described for many psychiatric
and neurologic conditions. However, a decade after the Research Domain Criteria launch …

The current epidemic of COVID-19 has gained attention and highlighted the need for a
better understanding of the population's mental health. Diet has been identified as an …

Introduction: Depression is a common non-motor symptom in Parkinson disease (PD),
occurring in approximately 20% of patients with PD. While depression can occur anytime in …

Background: The coronavirus disease 2019 (COVID-19) pandemic represents a condition of
increased vulnerability and frailty for elderly patients with Parkinson's disease (PD). Social …

Evidence supports inflammatory involvement in mood and cognitive symptoms across
psychiatric, neurological and medical disorders; however, inflammation is not a sensitive or …

Parkinson's disease (PD) is essentially characterized by the motor symptoms in the form of
resting tremor, rigidity and bradykinesia. However, over the years it has been recognized …

Introduction Non-motor symptoms (NMS) affect patients with Parkinson's disease (PD) from
the prodromal to the advanced stages. NMS phenotypes greatly vary and have a huge …