It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

Microtubule nucleation is regulated by the γ-tubulin ring complex (γTuRC) and related γ-
tubulin complexes, providing spatial and temporal control over the initiation of microtubule …

Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays.
They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic …

Centrosome amplification has long been recognized as a feature of human tumours;
however, its role in tumorigenesis remains unclear. Centrosome amplification is poorly …

The centrosome is the main microtubule organization centre of animal cells. It is composed
of a centriole pair surrounded by pericentriolar material (PCM). Traditionally described as …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Centrioles/basal bodies (CBBs) are microtubule-based cylindrical organelles that nucleate
the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral …

Centrioles are barrel-shaped structures that are essential for the formation of centrosomes,
cilia, and flagella. Here we review recent advances in our understanding of the function and …

The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …

The centriole is an evolutionarily conserved macromolecular structure that is crucial for the
formation of flagella, cilia and centrosomes. The ultrastructure of the centriole was first …