Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

Ageing is a complex process that negatively impacts the development of the immune system
and its ability to function. The mechanisms that underlie these age‐related defects are broad …

Physiological ageing is accompanied by decline in immune system function and immune
alteration during ageing increases susceptibility to infections. We retrospectively analysed …

В монографии проанализированы основные концепции о природе старения, история
их возникновения и эволюция. Изложены современные представления о …

A diet deficient in the amino acid methionine has previously been shown to extend lifespan
in several stocks of inbred rats. We report here that a methionine‐deficient (Meth‐R) diet …

Multiple mechanisms of tolerance are induced by oral antigen. Low doses favor active
suppression, whereas higher doses favor clonal anergy/deletion. Oral antigen induces T …

Age-related macular degeneration (AMD) is a disease of the outer retina, characterized most
significantly by atrophy of photoreceptors and retinal pigment epithelium accompanied with …

A diverse T cell repertoire is essential for a vigorous immune response to new infections,
and decreasing repertoire diversity has been implicated in the age-associated decline in …

As a part of an ongoing longitudinal investigation, this study examined relationships
between survival and selected immune system parameters in a sample (n= 102) of very old …

An extensive literature suggesting that PRL, GH, IGF-I, and thyroid hormones play an
important role in immunity has evolved. Because the use of one or more of these hormones …