The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …

Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Originally discovered almost a century ago, cocrystals continue to gain interest in the
modern day due to their ability to modify the physical properties of solid-state materials …

In recent years cocrystal formation has emerged as a viable strategy towards improving the
solubility and bioavailability of poorly soluble drugs. In this review the success of numerous …

The current phase of drug development is witnessing an oncoming crisis due to the
combined effects of increasing R&D costs, decreasing number of new drug molecules being …

Over the last 20 years, the number of publications outlining the advances in design
strategies, growing techniques, and characterization of cocrystals has continued to increase …

In the past several years, ionic liquids (ILs) have been at the cutting edge of the most
promising science and technology. ILs not only have found applications in classical areas of …

Crystallization is crucial in the pharmaceutical industry as a separation process for
intermediates and as the final step in the manufacture of active pharmaceutical ingredients …

The pharmaceutical industries face a series of challenges in the delivery of many newly
developed drug molecules because of their low solubility, bioavailability, stability and …

Salt and cocrystal formation are the most commonly used method of increasing solubility
and dissolution rate of pharmaceutical compounds, and are of particular interest for …