The traditional definition of natural antibodies (NAbs) states that these antibodies are
present prior to the body encountering cognate antigen, providing a first line of defense …

B lymphocytes were originally described as a cell type uniquely capable of secreting Abs.
The importance of T cell help in Ab production was revealed soon afterward. Following …

The immune systems of all mammals include populations of B cells producing antibodies
with incredibly diverse specificities. Repertoire diversity has been described as the “miracle …

The B-cell response in atherosclerosis is directed toward oxidation-specific epitopes such as
phosphorylcholine (PC) that arise during disease-driven oxidation of self-antigens. PC …

Streptococcus pneumoniae is the most common cause of pneumonia, which claims the lives
of people over the age of 65 y seven times more frequently than those aged 5–49 y. B-1a …

B-1 cells are a unique subset of B cells that are positively selected for expressing
autoreactive BCRs. We isolated RNA from peritoneal (B-1a, B-1b, B-2) and splenic (B-1a …

B-1 cells produce natural Abs which provide an integral first line of defense against
pathogens while also performing important homeostatic housekeeping functions. In this …

The chronic autoimmune inflammatory diseases, systemic lupus erythematosus and
Sjogren's syndrome, develop when tolerance to apoptotic cells (ACs) is lost. We have …

Introduction Natural antibody (NAb) derived from CD5+ B-1 cells maintains tissue
homeostasis, controls inflammation, aids in establishing long-term protective responses …

In the adult mouse, three major subsets of mature B-lymphocytes are recognized: B-1,
marginal zone (MZ), and follicular (FO) B cells. These B lymphocytes are the products of B …