Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
Myc is a powerful transcription factor implicated in epigenetic reprogramming, cellular
plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely …
plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely …
A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
RG Jones III, A Dimet‐Wiley, A Haghani… - The Journal of …, 2023 - Wiley Online Library
Exercise promotes functional improvements in aged tissues, but the extent to which it
simulates partial molecular reprogramming is unknown. Using transcriptome profiling from …
simulates partial molecular reprogramming is unknown. Using transcriptome profiling from …
Exome-wide association study of competitive performance in elite athletes
The aim of the study was to identify genetic variants associated with personal best scores in
Turkish track and field athletes and to compare allelic frequencies between sprint/power and …
Turkish track and field athletes and to compare allelic frequencies between sprint/power and …
Aerobic exercise training resets the human skeletal muscle methylome 10 years after breast cancer treatment and survival
Cancer survivors suffer impairments in skeletal muscle in terms of reduced mass and
function. Interestingly, human skeletal muscle possesses an epigenetic memory of earlier …
function. Interestingly, human skeletal muscle possesses an epigenetic memory of earlier …
Resistance and endurance exercise training improves muscle mass and the inflammatory/fibrotic transcriptome in a rhabdomyosarcoma model
N Collao, O Sanders, T Caminiti… - Journal of cachexia …, 2023 - Wiley Online Library
Background Rhabdomyosarcoma (RMS) is an aggressive soft tissue sarcoma that most
often develops in children. Chemoradiation therapy is a standard treatment modality; …
often develops in children. Chemoradiation therapy is a standard treatment modality; …
[HTML][HTML] Going nuclear: molecular adaptations to exercise mediated by myonuclei
Muscle fibers are multinucleated, and muscle fiber nuclei (myonuclei) are believed to be
post-mitotic and are typically situated near the periphery of the myofiber. Due to the unique …
post-mitotic and are typically situated near the periphery of the myofiber. Due to the unique …
Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice
Human hallmarks of sarcopenia include muscle weakness and a blunted response to
exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and …
exercise. Nicotinamide N-methyltransferase inhibitors (NNMTis) increase strength and …
Depressed Protein Synthesis and Anabolic Signaling Potentiate ACL Tear–Resultant Quadriceps Atrophy
Background: Anterior cruciate ligament (ACL) tear (ACLT) leads to protracted quadriceps
muscle atrophy. Protein turnover largely dictates muscle size and is highly responsive to …
muscle atrophy. Protein turnover largely dictates muscle size and is highly responsive to …
DNA Methylation in the Adaptive Response to Exercise
AJ Bittel, YW Chen - Sports Medicine, 2024 - Springer
Emerging evidence published over the past decade has highlighted the role of DNA
methylation in skeletal muscle function and health, including as an epigenetic transducer of …
methylation in skeletal muscle function and health, including as an epigenetic transducer of …
Acetate and succinate benefit host muscle energetics as exercise‐associated post‐biotics
Recently, the gut microbiome has emerged as a potent modulator of exercise‐induced
systemic adaptation and appears to be crucial for mediating some of the benefits of exercise …
systemic adaptation and appears to be crucial for mediating some of the benefits of exercise …