Endocannabinoids (eCBs) are amongst the most ubiquitous signaling molecules in the
nervous system. Over the past few decades, observations based on a large volume of work …

The endocannabinoid system consists of G protein-coupled cannabinoid CB 1 and CB 2
receptors, of endogenous compounds known as endocannabinoids that can target these …

There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9 …

The classical studies of nicotine by Langley at the turn of the 20th century introduced the
concept of a “receptive substance,” from which the idea of a “receptor” came to light …

The endocannabinoid system was revealed following the understanding of the mechanism
of action of marijuana's major psychotropic principle, Δ 9-tetrahydrocannabinol, and …

After their discovery, the two known cannabinoid receptors, CB1 and CB2, have been the
focus of research into the cellular signalling mechanisms of cannabinoids. The initial …

A rather complex and pleiotropic endogenous signalling system was discovered in the late
1990s, starting from studies on the mechanism of action of Δ9-tetrahydrocannabinol, the …

The CB 1 cannabinoid receptor is widely distributed in the central and peripheral nervous
system. Within the neuron, the CB 1 receptor is often localised in axon terminals, and its …

Nicotine stimulates the activity of mesolimbic dopamine neurons, which is believed to
mediate the rewarding and addictive properties of tobacco use. Accumulating evidence …

Diseases associated with tobacco use constitute a major health problem worldwide. Upon
cessation of tobacco use, an unpleasant withdrawal syndrome occurs in dependent …