Drug repurposing holds the potential to bring medications with known safety profiles to new
patient populations. Numerous examples exist for the identification of new indications for …

In recent decades, in silico absorption, distribution, metabolism, excretion (ADME), and
toxicity (T) modelling as a tool for rational drug design has received considerable attention …

Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) is a premier
public resource for literature-based, manually curated associations between chemicals …

Ten years ago, the Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) was
developed out of a need to formalize, harmonize and centralize the information on …

Background The acquisition of resistance to chemotherapy is a major hurdle in the
successful application of cancer therapy. Several anticancer approaches, including …

Abstract Motivation Knowledge graphs (KGs) are being adopted in industry, commerce and
academia. Biomedical KG presents a challenge due to the complexity, size and …

Complex biological systems are traditionally modelled as graphs of interconnected
biological entities. These graphs, ie biological knowledge graphs, are then processed using …

Efforts to maximize the indications potential and revenue from drugs that are already
marketed are largely motivated by what Sir James Black, a Nobel Prize-winning …

Given the tremendous growth of bioactivity databases, the use of computational tools to
predict protein targets of small molecules has been gaining importance in recent years …

Background: Drug repositioning is a new research area in drug development. It aims to
discover novel therapeutic uses of existing drugs. It could accelerate the process of …