All eukaryotic cells have an extensive membranous labyrinth network of branching tubules
and flattened sacs called the endoplasmic reticulum (ER). Approximately one-third of all …

This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

When unfolded proteins accumulate in the endoplasmic reticulum (ER), transcription of
glucose-regulated proteins (GRPs) representing ER-resident molecular chaperones is …

A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is
the induction of members of the glucose-regulated protein (Grp) family. The induction of …

The Y‐box‐binding protein (YB‐1) represents the most evolutionary conserved nucleic‐acid‐
binding protein currently known. YB‐1 is a member of the cold‐shock domain (CSD) protein …

ATF6, a member of the leucine zipper protein family, can constitutively induce the promoter
of glucose-regulated protein (grp) genes through activation of the endoplasmic reticulum …

Regulated mRNA turnover is a highly important process, but its mechanism is poorly
understood. Using interleukin-2 (IL-2) mRNA as a model, we described a role for the JNK …

The discovery of predictive factors for chemoresistance is critical for improving adjuvant
therapy for cancer patients. The 78-kDa glucose-regulated protein (GRP78), widely used as …

The endoplasmic reticulum (ER) serves several important functions. Cholesterol, an
essential component of cellular membranes, is synthesized on the ER surface. Inside the …

Y-box proteins are multifunctional regulators of gene expression. In somatic cells, they have
the capacity to exert positive and negative effects on both transcription and translation. In …