Despite the success of targeted therapies in cancer treatment, therapy-induced resistance
remains a major obstacle to a complete cure. Tumor cells evade treatments and relapse via …

Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

Although we have come a long way in our understanding of the signals that drive cancer
growth, and how these signals can be targeted, effective control of this disease remains a …

Blood and immune cells derive from multipotent hematopoietic stem cells (HSCs).
Classically, stem and progenitor populations have been considered discrete homogeneous …

Both intrinsic cell state changes and variations in the composition of stem cell populations
have been implicated as contributors to aging. We used single-cell RNA-seq to dissect …

A single hematopoietic stem cell (HSC) is capable of reconstituting hematopoiesis and
maintaining homeostasis by balancing self-renewal and cell differentiation. The …

Stem-cell function is an exquisitely regulated process. Thus far, the contribution of metabolic
cues to stem-cell function has not been well understood. Here we identify a previously …

Stem cells balance cellular fates through asymmetric and symmetric divisions in order to self-
renew or to generate downstream progenitors. Symmetric commitment divisions in stem …

The hypothesis that cancer is driven by tumour-initiating cells (popularly known as cancer
stem cells) has recently attracted a great deal of attention, owing to the promise of a novel …

Haematopoietic stem cells self-renew and differentiate into all blood lineages throughout
life, and can repair damaged blood systems upon transplantation. Asymmetric cell division …