Bioactive compounds and pharmacological and food applications of Syzygium cumini–a review

N Chhikara, R Kaur, S Jaglan, P Sharma, Y Gat… - Food & function, 2018 - pubs.rsc.org
The present review explores the nutritional, phytochemical and pharmacological potential as
well as diverse food usages of Syzygium cumini. S. cumini is a traditional medicinal plant …

Phytochemical Profile, Biological Properties, and Food Applications of the Medicinal Plant Syzygium cumini

M Qamar, S Akhtar, T Ismail, M Wahid, MW Abbas… - Foods, 2022 - mdpi.com
Syzygium cumini, locally known as Jamun in Asia, is a fruit-bearing crop belonging to the
Myrtaceae family. This study aims to summarize the most recent literature related to botany …

Discovery of tropifexor (LJN452), a highly potent non-bile acid FXR agonist for the treatment of cholestatic liver diseases and nonalcoholic steatohepatitis (NASH)

DC Tully, PV Rucker, D Chianelli, J Williams, A Vidal… - 2017 - ACS Publications
The farnesoid X receptor (FXR) is a nuclear receptor that acts as a master regulator of bile
acid metabolism and signaling. Activation of FXR inhibits bile acid synthesis and increases …

Jamun (Syzygium cumini (L.) Skeels) Seed: A Review on Nutritional Profile, Functional Food Properties, Health-Promoting Applications, and Safety Aspects

M Kumar, B Zhang, J Nishad, A Verma, V Sheri… - Processes, 2022 - mdpi.com
Jamun (Syzygium cumini L. Skeels) is highly perishable with a very short shelf life, hence,
jamun fruit is either consumed fresh as soon as it is harvested or converted to value-added …

A dual modulator of farnesoid X receptor and soluble epoxide hydrolase to counter nonalcoholic steatohepatitis

J Schmidt, M Rotter, T Weiser, S Wittmann… - Journal of medicinal …, 2017 - ACS Publications
Nonalcoholic steatohepatitis arising from Western diet and lifestyle is characterized by
accumulation of fat in liver causing inflammation and fibrosis. It evolves as serious health …

Jamun (Syzygium cumini (L.) Skeels) seed bioactives and its biological activities: A review

M Kumar, M Hasan, JM Lorenzo, S Dhumal, J Nishad… - Food Bioscience, 2022 - Elsevier
Abstract Jamun (Syzygium cumini Skeels) is a nutritious fruit and has historically been used
as both as an edible and a traditional medicine. The jamun seed is an inedible by-product of …

Deciphering the structural determinants critical in attaining the FXR partial agonism

A Kumari, L Mittal, M Srivastava… - The Journal of …, 2023 - ACS Publications
Elucidation of structural determinants is pivotal for structure-based drug discovery. The
Farnesoid X receptor (FXR) is a proven target for NASH; however, its full agonism causes …

The role of bile acids in the human body and in the development of diseases

Y Shulpekova, M Zharkova, P Tkachenko, I Tikhonov… - Molecules, 2022 - mdpi.com
Bile acids are specific and quantitatively important organic components of bile, which are
synthesized by hepatocytes from cholesterol and are involved in the osmotic process that …

Autophagy modulators in coronavirus diseases: a double strike in viral burden and inflammation

RCMC Silva, JS Ribeiro, GPD da Silva… - Frontiers in Cellular …, 2022 - frontiersin.org
Coronaviruses are the etiologic agents of several diseases. Coronaviruses of critical
medical importance are characterized by highly inflammatory pathophysiology, involving …

Insights into the phenolic compounds present in jambolan (Syzygium cumini) along with their health‐promoting effects

B Singh, JP Singh, A Kaur… - International Journal of …, 2018 - Wiley Online Library
Jambolan is a rich source of bioactive phenolic compounds that have many potential health
benefits. Phenolic acids, flavonoids (mainly anthocyanins, flavonols, flavanols and …