BACKGROUND Progesterone is a key hormonal regulator of the female reproductive
system. It plays a major role to prepare the uterus for implantation and in the establishment …

Research involving estrogen and progesterone receptors (ER and PR) have greatly
contributed to our understanding of cell signaling and transcriptional regulation. In addition …

The human progesterone receptor (PR) is a ligand-dependent transcription factor and two
isoforms,(PRA and PRB), can be distinguished. PROGINS, a PR polymorphic variant, affects …

We earlier identified a lysine to arginine transition at residue 303 (K303R) in estrogen
receptor alpha (ERα) in invasive breast cancers, which confers resistance to the aromatase …

Purpose Recurrent pregnancy loss (RPL) could be caused by insufficient progesterone in
the luteal phase of menstruation and early pregnancy. Progesterone plays a critical role in …

OBJECTIVE: To investigate the genetic association between estrogen and progesterone
receptor polymorphisms (ER, PR) and skewed X chromosome inactivation (XCI) and …

Bolton KL, Ganda C, Berchuck A, Pharaoh PDP, Gayther SA (National Cancer Institute,
Rockville, MD, USA; EGA Institute for Women's Health, University College London, London …

Aberrant DNA methylation is an important molecular alteration commonly detected in
various malignancies. Hypermethylation and expression silencing have been frequently …

Background The relationship between single nucleotide polymorphisms (SNPs) and ovarian
cancer (OC) risk remains controversial. This systematic review and network meta‐analysis …

Genes encoding hormone receptors are among candidate genes modulating the risk of
ovarian cancer. We aimed to assess a frequency of PGRG+ 331A, FSHRAla307Thr, and …