Pathogenesis of chronic obstructive pulmonary disease

RM Tuder, I Petrache - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
The current epidemic of chronic obstructive pulmonary disease (COPD) has produced a
worldwide health care burden, approaching that imposed by transmittable infectious …

Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments

L Zuo, F He, GG Sergakis… - … of Physiology-Lung …, 2014 - journals.physiology.org
Cigarette smoking (CS) can impact the immune system and induce pulmonary disorders
such as chronic obstructive pulmonary disease (COPD), which is currently the fourth leading …

[HTML][HTML] Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures

KS Schweitzer, SX Chen, S Law… - … of Physiology-Lung …, 2015 - journals.physiology.org
The increased use of inhaled nicotine via e-cigarettes has unknown risks to lung health.
Having previously shown that cigarette smoke (CS) extract disrupts the lung …

[HTML][HTML] Inhalation toxicology of vaping products and implications for pulmonary health

H Traboulsi, M Cherian, M Abou Rjeili… - International journal of …, 2020 - mdpi.com
E-cigarettes have a liquid that may contain flavors, solvents, and nicotine. Heating this liquid
generates an aerosol that is inhaled into the lungs in a process commonly referred to as …

[HTML][HTML] The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells

I Corre, F Paris, J Huot - Oncotarget, 2017 - ncbi.nlm.nih.gov
By gating the traffic of molecules and cells across the vessel wall, endothelial cells play a
central role in regulating cardiovascular functions and systemic homeostasis and in …

Personalized medicine for patients with COPD: where are we?

FME Franssen, P Alter, N Bar… - … journal of chronic …, 2019 - Taylor & Francis
Chronic airflow limitation is the common denominator of patients with chronic obstructive
pulmonary disease (COPD). However, it is not possible to predict morbidity and mortality of …

Structural and functional characterization of endothelial microparticles released by cigarette smoke

KA Serban, S Rezania, DN Petrusca, C Poirier… - Scientific reports, 2016 - nature.com
Circulating endothelial microparticles (EMPs) are emerging as biomarkers of chronic
obstructive pulmonary disease (COPD) in individuals exposed to cigarette smoke (CS), but …

Unique lipid signatures of extracellular vesicles from the airways of asthmatics

KP Hough, LS Wilson, JL Trevor, JG Strenkowski… - Scientific reports, 2018 - nature.com
Asthma is a chronic inflammatory disease process involving the conductive airways of the
human lung. The dysregulated inflammatory response in this disease process may involve …

Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes

RP Bowler, S Jacobson, C Cruickshank… - American journal of …, 2015 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) occurs in a minority of smokers
and is characterized by intermittent exacerbations and clinical subphenotypes such as …

Effects of cigarette smoke on pulmonary endothelial cells

Q Lu, E Gottlieb, S Rounds - American Journal of …, 2018 - journals.physiology.org
Cigarette smoking is the leading cause of preventable disease and death in the United
States. Cardiovascular comorbidities associated with both active and secondhand cigarette …