Roadmap for advancing pre-clinical science in traumatic brain injury

DH Smith, PM Kochanek, S Rosi, R Meyer… - Journal of …, 2021 - liebertpub.com
Pre-clinical models of disease have long played important roles in the advancement of new
treatments. However, in traumatic brain injury (TBI), despite the availability of numerous …

Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits

I Özen, H Mai, A De Maio, K Ruscher… - Acta neuropathologica …, 2022 - Springer
Cerebellar dysfunction is commonly observed following traumatic brain injury (TBI). While
direct impact to the cerebellum by TBI is rare, cerebellar pathology may be caused by …

Diffuse traumatic injury in the mouse disrupts axon-myelin integrity in the cerebellum

I Özen, S Arkan, F Clausen, K Ruscher… - Journal of …, 2022 - liebertpub.com
Cerebellar dysfunction after traumatic brain injury (TBI) is commonly suspected based on
clinical symptoms, although cerebellar pathology has rarely been investigated. To address …

Initiators of classical and lectin complement pathways are differently engaged after traumatic brain injury—time-dependent changes in the cortex, striatum, thalamus …

A Ciechanowska, K Ciapała, K Pawlik… - International journal of …, 2020 - mdpi.com
The complement system is involved in promoting secondary injury after traumatic brain
injury (TBI), but the roles of the classical and lectin pathways leading to complement …

Overexpression of astrocytes-specific GJA1-20k enhances the viability and recovery of the neurons in a rat model of traumatic brain injury

D Ren, P Zheng, J Feng, Y Gong, Y Wang… - ACS Chemical …, 2020 - ACS Publications
Traumatic brain injury (TBI) is a devastating actuality in clinics worldwide. It is estimated that
approximately 10 million people among the world suffer from TBI each year, and a …

An air-filled bicycle helmet for mitigating traumatic brain injury

B Mathon, V Duarte Rocha, JB Py, A Falcan, T Bergeret - Bioengineering, 2023 - mdpi.com
We created a novel air-filled bicycle helmet. The aims of this study were (i) to assess the
head injury mitigation performance of the proposed helmet and (ii) to compare those …

Neutralization of interleukin1-beta is associated with preservation of thalamiccapillaries after experimental traumatic brain injury

I Özen, F Clausen, J Flygt, N Marklund… - Frontiers in …, 2024 - frontiersin.org
Introduction Traumatic brain injury to thalamo-cortical pathways is associated with
posttraumatic morbidity. Diffuse mechanical forces to white matter tracts and deep grey …

Spatial distribution of neuropathology and neuroinflammation elucidate the biomechanics of fluid percussion injury

JA Beitchman, J Lifshitz, NG Harris… - Neurotrauma …, 2021 - liebertpub.com
Diffuse brain injury is better described as multi-focal, where pathology can be found
adjacent to seemingly uninjured neural tissue. In experimental diffuse brain injury, pathology …

Development and application of a novel pressure system for evaluating trauma severities using a physiological approach after traumatic brain injury in rats

RS do Nascimento, JLB Marques, ARS Santos… - World Neurosurgery, 2023 - Elsevier
Objective The fluid percussion injury (FPI) model is a surgical method for mimicking
traumatic brain injury (TBI) models as it automatically and accurately measures peak impact …

Assessment of the effects of stretch-injury on primary rat microglia

M Shaughness, K Byrnes - Molecular Neurobiology, 2021 - Springer
Mechanical stretch-injury is a prominent force involved in the etiology of traumatic brain
injury (TBI). It is known to directly cause damage and dysfunction in neurons, astrocytes, and …