A guide to plasma membrane solute carrier proteins

MD Pizzagalli, A Bensimon… - The FEBS …, 2021 - Wiley Online Library
This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily
of transporter proteins and their roles in human cells. The SLC superfamily currently …

[HTML][HTML] Role of estrogen receptors in health and disease

P Chen, B Li, L Ou-Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Estrogen receptors (ERs) regulate multiple complex physiological processes in humans.
Abnormal ER signaling may result in various disorders, including reproductive system …

The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

SD Harding, JF Armstrong, E Faccenda… - Nucleic Acids …, 2022 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; www.
guidetopharmacology. org) is an open-access, expert-curated database of molecular …

[HTML][HTML] Anxiety, depression, and the microbiome: a role for gut peptides

G Lach, H Schellekens, TG Dinan, JF Cryan - Neurotherapeutics, 2018 - Elsevier
The complex bidirectional communication between the gut and the brain is finely
orchestrated by different systems, including the endocrine, immune, autonomic, and enteric …

The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA …

JF Armstrong, E Faccenda, SD Harding… - Nucleic acids …, 2020 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (www. guidetopharmacology. org) is
an open-access, expert-curated database of molecular interactions between ligands and …

The IUPHAR/BPS guide to pharmaCOLOGY in 2024

SD Harding, JF Armstrong, E Faccenda… - Nucleic acids …, 2024 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.
guidetopharmacology. org) is an open-access, expert-curated, online database that …

A new ESI-LC/MS approach for comprehensive metabolic profiling of phytocannabinoids in Cannabis

P Berman, K Futoran, GM Lewitus, D Mukha… - Scientific reports, 2018 - nature.com
Most clinical studies of Cannabis today focus on the contents of two phytocannabinoids:(-)-
Δ9-trans-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), regardless of the fact that …

Biased allosteric modulators: new frontiers in GPCR drug discovery

LM Slosky, MG Caron, LS Barak - Trends in pharmacological sciences, 2021 - cell.com
G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in the
genome and the most successful family of targets of FDA-approved drugs. New frontiers in …

A benzohydrazide-based artificial ion channel that modulates chloride ion concentration in cancer cells and induces apoptosis by disruption of autophagy

A Mondal, SN Save, S Sarkar, D Mondal… - Journal of the …, 2023 - ACS Publications
Fluctuations in the intracellular chloride ion concentration, mediated by synthetic ion
transporters, have been known to induce cytotoxicity in cells by disrupting ionic …

ChEMBL: a large-scale bioactivity database for drug discovery

A Gaulton, LJ Bellis, AP Bento, J Chambers… - Nucleic acids …, 2012 - academic.oup.com
Abstract ChEMBL is an Open Data database containing binding, functional and ADMET
information for a large number of drug-like bioactive compounds. These data are manually …