Structure, dynamics and function of the 26S proteasome
Y Mao - Macromolecular protein complexes III: structure and …, 2021 - Springer
The 26S proteasome is the most complex ATP-dependent protease machinery, of~ 2.5 MDa
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …
mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated …
Proteasome substrate receptors and their therapeutic potential
V Osei-Amponsa, KJ Walters - Trends in biochemical sciences, 2022 - cell.com
The ubiquitin-proteasome system (UPS) is critical for protein quality control and regulating
protein lifespans. Following ubiquitination, UPS substrates bind multidomain receptors that …
protein lifespans. Following ubiquitination, UPS substrates bind multidomain receptors that …
Development of a novel PROTAC using the nucleic acid aptamer as a targeting ligand for tumor selective degradation of nucleolin
L Zhang, L Li, X Wang, H Liu, Y Zhang, T Xie… - … Therapy-Nucleic Acids, 2022 - cell.com
PROteolysis TArgeting Chimeras (PROTACs) induce targeted protein degradation by
hijacking the intracellular ubiquitin proteasome system, thus emerging as a new strategy for …
hijacking the intracellular ubiquitin proteasome system, thus emerging as a new strategy for …
[HTML][HTML] Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice
The E3 ubiquitin ligase Ube3a is biallelically expressed in neural progenitors and glial cells,
suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental …
suggesting that UBE3A gain-of-function mutations might cause neurodevelopmental …
Proteasome interaction with ubiquitinated substrates: from mechanisms to therapies
The 26S proteasome is responsible for regulated proteolysis in eukaryotic cells. Its
substrates are diverse in structure, function, sequence length, and amino acid composition …
substrates are diverse in structure, function, sequence length, and amino acid composition …
Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma
Proteasome substrate receptor hRpn13 is a promising anti-cancer target. By integrated in
silico and biophysical screening, we identified a chemical scaffold that binds hRpn13 with …
silico and biophysical screening, we identified a chemical scaffold that binds hRpn13 with …
E6AP AZUL interaction with UBQLN1/2 in cells, condensates, and an AlphaFold-NMR integrated structure
Summary The E3 ligase E6AP/UBE3A has a dedicated binding site in the 26S proteasome
provided by the RAZUL domain of substrate receptor hRpn10/S5a/PSMD4. Guided by …
provided by the RAZUL domain of substrate receptor hRpn10/S5a/PSMD4. Guided by …
[HTML][HTML] Exploration of aberrant E3 ligases implicated in Alzheimer's disease and development of chemical tools to modulate their function
FM Potjewyd, AD Axtman - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
The Ubiquitin Proteasome System (UPS) is responsible for the degradation of misfolded or
aggregated proteins via a multistep ATP-dependent proteolytic mechanism. This process …
aggregated proteins via a multistep ATP-dependent proteolytic mechanism. This process …
Exploring the “Other” subfamily of HECT E3-ligases for therapeutic intervention
S Singh, J Ng, J Sivaraman - Pharmacology & Therapeutics, 2021 - Elsevier
The HECT E3 ligase family regulates key cellular signaling pathways, with its 28 members
divided into three subfamilies: NEDD4 subfamily (9 members), HERC subfamily (6 …
divided into three subfamilies: NEDD4 subfamily (9 members), HERC subfamily (6 …
Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6
Human papillomavirus (HPV) infections account for nearly all cervical cancer cases, which is
the fourth most common cancer in women worldwide. High-risk variants, including HPV16 …
the fourth most common cancer in women worldwide. High-risk variants, including HPV16 …