[HTML][HTML] How much does it cost to research and develop a new drug? A systematic review and assessment
M Schlander, K Hernandez-Villafuerte, CY Cheng… - …, 2021 - Springer
Background Debate over the viability of the current commercial research and development
(R&D) model is ongoing. A controversial theme is the cost of bringing a new molecular entity …
(R&D) model is ongoing. A controversial theme is the cost of bringing a new molecular entity …
Therapies for rare diseases: therapeutic modalities, progress and challenges ahead
E Tambuyzer, B Vandendriessche, CP Austin… - Nature Reviews Drug …, 2020 - nature.com
Most rare diseases still lack approved treatments despite major advances in research
providing the tools to understand their molecular basis, as well as legislation providing …
providing the tools to understand their molecular basis, as well as legislation providing …
Estimated research and development investment needed to bring a new medicine to market, 2009-2018
Importance The mean cost of developing a new drug has been the subject of debate, with
recent estimates ranging from $314 million to $2.8 billion. Objective To estimate the …
recent estimates ranging from $314 million to $2.8 billion. Objective To estimate the …
An overview of drug discovery and development
N Berdigaliyev, M Aljofan - Future medicinal chemistry, 2020 - Taylor & Francis
A new medicine will take an average of 10–15 years and more than US $2 billion before it
can reach the pharmacy shelf. Traditionally, drug discovery relied on natural products as the …
can reach the pharmacy shelf. Traditionally, drug discovery relied on natural products as the …
[HTML][HTML] Special FDA designations for drug development: orphan, fast track, accelerated approval, priority review, and breakthrough therapy
DT Michaeli, T Michaeli, S Albers, T Boch… - The European Journal of …, 2024 - Springer
Background Over the past decades, US Congress enabled the US Food and Drug
Administration (FDA) to facilitate and expedite drug development for serious conditions …
Administration (FDA) to facilitate and expedite drug development for serious conditions …
[HTML][HTML] Pricing of pharmaceuticals is becoming a major challenge for health systems
Pricing of pharmaceuticals is becoming a major challenge for health systems | The BMJ
Skip to main content Intended for healthcare professionals Access provided by Google …
Skip to main content Intended for healthcare professionals Access provided by Google …
Do drug‐likeness rules apply to oral prodrugs?
ÍF Protti, DR Rodrigues, SK Fonseca, RJ Alves… - …, 2021 - Wiley Online Library
This paper describes a comparative analysis of the physicochemical and structural
properties of prodrugs and their corresponding drugs with regard to drug‐likeness rules. The …
properties of prodrugs and their corresponding drugs with regard to drug‐likeness rules. The …
Knowledge-based approaches to drug discovery for rare diseases
The conventional drug discovery pipeline has proven to be unsustainable for rare diseases.
Herein, we discuss recent advances in biomedical knowledge mining applied to discovering …
Herein, we discuss recent advances in biomedical knowledge mining applied to discovering …
Costs of drug development and research and development intensity in the US, 2000-2018
A Sertkaya, T Beleche, A Jessup… - JAMA Network …, 2024 - jamanetwork.com
Importance Understanding the cost of drug development can help inform the development of
policies to reduce costs, encourage innovation, and improve patient access to drugs …
policies to reduce costs, encourage innovation, and improve patient access to drugs …
Drug discovery and development in rare diseases: taking a closer look at the tafamidis story
A Burton, A Castaño, M Bruno, S Riley… - Drug design …, 2021 - Taylor & Francis
Rare diseases are increasingly recognized as a global public health priority. Governments
worldwide currently provide important incentives to stimulate the discovery and development …
worldwide currently provide important incentives to stimulate the discovery and development …