Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

Clonal hematopoiesis driven by DNMT3A and TET2 mutations: ro... : Current Opinion in
Hematology Clonal hematopoiesis driven by DNMT3A and TET2 mutations: role in …

Richter syndrome (RS) arising from chronic lymphocytic leukemia (CLL) exemplifies an
aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics …

Although the genetic landscape of chronic lymphocytic leukemia (CLL) has been broadly
profiled by large-scale sequencing studies performed over the past decade, the molecular …

Immune cells are an inseparable component of adipose tissue intimately involved in most of
its functions. Physiologically, they regulate adipose tissue homeostasis, while in case of …

B cells play a pivotal role in the pathogenesis of autoimmune diseases. Although previous
studies have shown many genetic polymorphisms associated with B-cell activation in …

Single-cell transcriptomics is the current gold standard for global gene expression profiling,
not only in mammals and model species, but also in non-model fish species. This is a rapidly …

CD21 low age-associated or atypical memory B cells are autoantibody enriched and poised
for plasma cell differentiation. These cells overaccumulate in chronic infections, autoimmune …

Preeclampsia (PE) is a leading cause of maternal and fetal mortality worldwide. The immune
system plays a critical role in normal pregnancy progression; however, inappropriate …

Chronic lymphocytic leukemia (CLL) is characterized by disordered DNA methylation,
suggesting these epigenetic changes might play a critical role in disease onset and …