While the tumor suppressor functions of p53 have long been recognized, the contribution of
p53 to numerous other aspects of disease and normal life is only now being appreciated …

The Y‐box binding protein 1 (YB‐1, YBX1) is a member of the family of DNA‐and RNA‐
binding proteins with an evolutionarily ancient and conserved cold shock domain. It falls into …

Inactivation of p53 is critical for the formation of most tumors. Illumination of the key function
(s) of p53 protein in protecting cells from becoming cancerous is therefore a worthy goal …

This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its
homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the …

The p53 tumour suppressor is modified through mutation or changes in expression in most
cancers, leading to the altered regulation of hundreds of genes that are directly influenced …

Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the
presence of one or more cold shock domains. In humans, the best characterized members of …

The central dogma of molecular biology describes the translation of genetic information from
mRNA to protein, but does not specify the quantitation or timing of this process across the …

p53 plays a key role in mediating cell response to various stresses, mainly by inducing or
repressing a number of genes involved in cell cycle arrest, senescence, apoptosis, DNA …

The complexity of the p53 protein, coupled with the vast cellular responses to p53, is simply
astonishing. As new isoforms, functional domains and protein–protein interactions are …

The Y Box binding protein 1 (YB-1) is a member of the highly conserved Cold Shock Domain
protein family with multifunctional properties both in the cytoplasm and inside the nucleus …