Beyond fuelling cellular activities with building blocks and energy, metabolism also
integrates environmental conditions into intracellular signals. The underlying regulatory …

The metabolite 2-oxoglutarate (also known as α-ketoglutarate, 2-ketoglutaric acid, or
oxoglutaric acid) lies at the intersection between the carbon and nitrogen metabolic …

Assimilation of nitrogen is an essential process in bacteria. The nitrogen regulation stress
response is an adaptive mechanism used by nitrogen-starved Escherichia coli to scavenge …

The human genitourinary tract is a common anatomical niche for polymicrobial infection and
a leading site for the development of bacteremia and sepsis. Most uncomplicated …

Enterohemorrhagic Escherichia coli (EHEC) is a major cause of severe bloody diarrhea,
with potentially lethal complications, such as hemolytic uremic syndrome. In humans, EHEC …

To cope with fluctuations in their environment, bacteria have evolved multiple adaptive
stress responses. One such response is the nitrogen regulation stress response, which …

Peptidoglycan (PG) hydrolases play important roles in various aspects of bacterial
physiology, including cytokinesis, PG synthesis, quality control of PG, PG recycling, and …

The CbrA/B system in pseudomonads is involved in the utilization of carbon sources and
carbon catabolite repression (CCR) through the activation of the small RNAs crcZ in …

Pseudomonas aeruginosa is a prime opportunistic pathogen, one of the most important
causes of hospital-acquired infections and the major cause of morbidity and mortality in …

Biosynthesis of fatty acids is one of the most fundamental biochemical pathways in nature. In
bacteria and plant chloroplasts, the committed and rate‐limiting step in fatty acid …