In his memorable book published in 1949, The Physics of High Pressure, 1 Bridgman states
that “it is a well-known result of thermodynamics that a substance is only completely …

Inherited myopathies affect both skeletal and cardiac muscle and are commonly associated
with genetic dysfunctions, leading to the production of anomalous proteins. In …

High pressure (HP) or urea is commonly used to disturb folding species. Pressure favors the
reversible unfolding of proteins by causing changes in the volumetric properties of the …

The hypertrophic cardiomyopathy-associated mutant D145E, in cardiac troponin C (cTnC) C-
domain, causes generalised instability at multiple sites in the isolated protein. As a result …

The ubiquitous Ca2+-sensing protein calmodulin (CaM) interacts with more than 300
diverse target proteins that are involved in numerous signaling pathways in eukaryotic cells …

Hypertrophic cardiomyopathy (HCM) is one of the most common cardiomyopathies, and a
major cause of sudden death in young athletes. The Ca 2+ sensor of the sarcomere, cardiac …

c-Abl is a key regulator of cell signaling and is under strict control via intramolecular
interactions. In this study, we address changes in the intramolecular dynamics coupling …

The cardiac contraction-relaxation cycle is controlled by a sophisticated set of machinery. Of
particular interest, is the revelation that allosteric networks transmit effects of binding at one …

Computational prediction of structure for macromolecular fragments is a formidable
challenge. Here we show that the differences in conformational thermodynamics, computed …

High pressure research can be used to aid in answering why some polypeptide chains
reversibly unfold and others adopt a misfolding conformation culminating in aggregation …