Recently, there has been an increasing interest in stoichiometric analysis of metabolic flux
distributions. Flux balance methods only require information about metabolic reaction …

In order to enhance the yield and productivity of metabolite production, researchers have
focused almost exclusively on enzyme amplification or other modifications of the product …

A stoichiometric model describing the anaerobic metabolism of Saccharomyces cerevisiae
during growth on a defined medium was derived. The model was used to calculate …

The two main contributions of this article are the solidification of Corynebacterium
glutamicum biochemistry guided by bioreaction network analysis, and the determination of …

The network structure and the metabolic fluxes in central carbon metabolism were
characterized in aerobically grown cells of Saccharomyces cerevisiae. The cells were grown …

To determine the in vivo fluxes of the central metabolism we have developed a
comprehensive approach exclusively based on the fundamental enzyme reactions known to …

In contrast to batch cultivation, chemostat cultivation allows the identification of carbon
source responses without interference by carbon-catabolite repression, accumulation of …

Mathematical models of the cellular metabolism have a special interest within
biotechnology. Many different kinds of commercially important products are derived from the …

Effects of furfural on the aerobic metabolism of the yeast Saccharomyces cerevisiae were
studied by performing chemostat experiments, and the kinetics of furfural conversion was …

The Escherichia coli K-12 strain TG1 was grown at 28° C in aerobic glucose-limited
continuous cultures at dilution rates ranging from 0· 044 to 0· 415 h− 1. The rates of biomass …