Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Inflammation is an important driver of atherosclerosis, the underlying pathology of
cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is …

Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …

Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3
(NLRP3) is an intracellular innate immune receptor that recognizes a diverse range of …

Inflammasome complexes and their integral receptor proteins have essential roles in
regulating the innate immune response and inflammation at the post-translational level. Yet …

Cardiovascular diseases (CVDs) are the prevalent cause of mortality around the world.
Activation of inflammasome contributes to the pathological progression of cardiovascular …

Rationale: Endothelial dysfunction results in sustained and chronic vascular inflammation,
which is central to atherosclerotic diseases. However, transcriptional regulation of vascular …

Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are
characterized by a chronic sterile inflammation in the large blood vessels, where lipid …

Chronic low-grade inflammation contributes to the development of several diseases,
including cardiovascular disease. Adequate strategies to target inflammation in …

Atherosclerosis underlies the leading cause of death in industrialized countries. 1
Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs …