Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties
DR Aboshouk, MA Youssef, MS Bekheit, AR Hamed… - RSC …, 2024 - pubs.rsc.org
Cancer is one of the most significant health challenges worldwide. Various techniques, tools
and therapeutics/materials have been developed in the last few decades for the treatment of …
and therapeutics/materials have been developed in the last few decades for the treatment of …
Novel chalcone derivatives of ursolic acid as acetylcholinesterase inhibitors: Synthesis, characterization, biological activity, ADME prediction, molecular docking and …
Acetylcholinesterase (AChE) is a critical target in the prevention of Alzheimer's Disease (AD)
progression. With the goal of developing potential acetylcholinesterase inhibitors, a new …
progression. With the goal of developing potential acetylcholinesterase inhibitors, a new …
Design, synthesis, and biological evaluation studies of novel naphthalene-chalcone hybrids as antimicrobial, anticandidal, anticancer, and VEGFR-2 inhibitors
D Osmaniye, BN Sağlık, N Khalilova, S Levent… - ACS …, 2023 - ACS Publications
Cancer is a progressive disease that is frequently encountered worldwide. The incidence of
cancer is increasing with the changing living conditions around the world. The side-effect …
cancer is increasing with the changing living conditions around the world. The side-effect …
The anticancer activity of bile acids in drug discovery and development
W Li, L Zou, S Huang, H Miao, K Liu, Y Geng… - Frontiers in …, 2024 - frontiersin.org
Bile acids (BAs) constitute essential components of cholesterol metabolites that are
synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the …
synthesized in the liver, stored in the gallbladder, and excreted into the intestine through the …
Chlamydia trachomatis infection co-operatively enhances HPV E6-E7 oncogenes mediated tumorigenesis and immunosuppression
N Challagundla, J Chrisophe-Bourdon… - Microbial …, 2023 - Elsevier
Chlamydia trachomatis and human papilloma virus (HPV) are the two most common
sexually transmitted infections among women. HPV infection can increase the risk of cervical …
sexually transmitted infections among women. HPV infection can increase the risk of cervical …
Mimicry of sorafenib: novel diarylureas as VEGFR2 inhibitors and apoptosis inducers in breast cancer
MMF Ismail, EM Husseiny, MH Ibrahim - New Journal of Chemistry, 2023 - pubs.rsc.org
Thirteen diarylurea derivatives were designed and synthesized as sorafenib mimetics. The
cytotoxic activity of the newly synthesized entities towards human breast cancer cell …
cytotoxic activity of the newly synthesized entities towards human breast cancer cell …
Synthesis of bile acid-thiadiazole conjugates as antibacterial and antioxidant agents
S Patel, S Mishra - Steroids, 2023 - Elsevier
The synthesis, characterization, and antibacterial and antioxidant activity of thiadiazole-
deoxycholic/lithocholic acid conjugates are described in this communication. The structures …
deoxycholic/lithocholic acid conjugates are described in this communication. The structures …
Multi-functional pH-responsive and biomimetic chitosan-based nanoplexes for targeted delivery of ciprofloxacin against bacterial sepsis
Bacterial sepsis is a mortal syndromic disease characterized by a complex pathophysiology
that hinders effective targeted therapy. This study aimed to develop multifunctional …
that hinders effective targeted therapy. This study aimed to develop multifunctional …
Novel coumarin-6-sulfonamide-chalcone hybrids as glutathione transferase P1-1 inhibitors
A Sabt, S Kitsos, MS Ebaid, V Furlan, PD Pantiora… - Plos one, 2024 - journals.plos.org
Multidrug resistance (MDR) mechanisms in cancer cells are greatly influenced by
glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as …
glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as …
Novel NO-TZDs and trimethoxychalcone-based DHPMs: design, synthesis, and biological evaluation as potential VEGFR-2 inhibitors
MH Mahnashi, M Nahari, H Almasoudi… - Journal of Enzyme …, 2024 - Taylor & Francis
Novel series of nitric oxide-releasing thiazolidine-2, 4-diones (NO-TZD-3a-d, 5, 6) and 3, 4, 5-
trimethoxychalcone-based multifunctional 1, 4-dihydropyrimidines (CDHPM-10a-g) have …
trimethoxychalcone-based multifunctional 1, 4-dihydropyrimidines (CDHPM-10a-g) have …