It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Advanced glycation end products (AGEs), formed through the nonenzymatic reaction of
reducing sugars with the side-chain amino groups of lysine or arginine of proteins, followed …

Epidemiological studies have suggested that cumulative diabetic exposure, namely
prolonged exposure to chronic hyperglycemia, contributes to the increased risk of …

The soluble receptor for advanced glycation end-products (sRAGE) has been classically
considered a sink for pro-inflammatory RAGE ligands and as such has been associated with …

The receptor for advanced glycation endproducts (RAGE) was first described as a signal
transduction receptor for advanced glycation endproducts (AGEs), the products of …

Diabetes is well established as a chronic disease with a high health burden due to mortality
or morbidity from the final outcomes of vascular complications. An increased duration of …

Background Advanced glycation end-products (AGEs) and their interaction with the receptor
for advanced glycation end-products (RAGE) play a pivotal role in the development and …

Biomarkers are conventionally defined as “biological molecules that represent health and
disease states.” They typically are measured in readily available body fluids (blood or urine) …

The discovery of the receptor for advanced glycation end-products (RAGE) set the stage for
the elucidation of important mechanisms underpinning diabetic complications. RAGE …

Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …