Structure of fish Toll-like receptors (TLR) and NOD-like receptors (NLR)

BR Sahoo - International journal of biological macromolecules, 2020 - Elsevier
Innate immunity driven by pattern recognition receptor (PRR) protects the host from invading
pathogens. Aquatic animals like fish where the adaptive immunity is poorly developed …

Molecular characterization, expression and functional analysis of NOD1, NOD2 and NLRC3 in Nile tilapia (Oreochromis niloticus)

F Gao, J Pang, M Lu, H Zhu, X Ke, Z Liu, J Cao… - Fish & shellfish …, 2018 - Elsevier
The nucleotide-binding oligomerization domain proteins NOD1, NOD2 and NLRC3 are
cytoplasmic pattern recognition receptors (PRRs) of the Nod-like receptor (NLR) family. In …

A genome-wide survey of expansive NLR-C subfamily in miiuy croaker and characterization of the NLR-B30. 2 genes

J Li, Q Chu, T Xu - Developmental & Comparative Immunology, 2016 - Elsevier
NOD-like receptors (NLRs) are essential intracellular pattern-recognition receptors that
respond to pathogens and regulate innate immunity. NLRs include three distinct subfamilies …

Involvement of ayu NOD2 in NF-κB and MAPK signaling pathways: insights into functional conservation of NOD2 in antibacterial innate immunity

Y Ren, SF Liu, L Nie, SY Cai, J Chen - Zoological Research, 2018 - pmc.ncbi.nlm.nih.gov
Nucleotide oligomerization domain 2 (NOD2) is a major cytoplasmic sensor for pathogens
and is critical for the clearance of cytosolic bacteria in mammals. However, studies regarding …

LRRsearch: an asynchronous server-based application for the prediction of leucine-rich repeat motifs and an integrative database of NOD-like receptors

A Bej, BR Sahoo, B Swain, M Basu… - Computers in biology …, 2014 - Elsevier
The leucine-rich repeat (LRR) motifs of the nucleotide-binding oligomerization domain like
receptors (NLRs) play key roles in recognizing and binding various pathogen associated …

Understanding the distinguishable structural and functional features in zebrafish TLR3 and TLR22, and their binding modes with fish dsRNA viruses: an exploratory …

BR Sahoo, MR Dikhit, GK Bhoi, J Maharana, SK Lenka… - Amino acids, 2015 - Springer
Viral infections are one of the major challenges in aquaculture production, and considered
as the potential threat for fish farming. Toll-like receptor (TLR) 3 and TLR22 are highly …

Structural insights into the MDP binding and CARD–CARD interaction in zebrafish (Danio rerio) NOD2: a molecular dynamics approach

J Maharana, MC Patra, BC De… - Journal of Molecular …, 2014 - Wiley Online Library
Nucleotide binding and oligomerization domain (NOD2) is a key component of innate
immunity that is highly specific for muramyl dipeptide (MDP)—a peptidoglycan component of …

Structural Models of Zebrafish (Danio rerio) NOD1 and NOD2 NACHT Domains Suggest Differential ATP Binding Orientations: Insights from Computational Modeling …

J Maharana, BR Sahoo, A Bej, I Jena, A Parida… - PLoS …, 2015 - journals.plos.org
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) and NOD2 are
cytosolic pattern recognition receptors playing pivotal roles in innate immune signaling …

Structural and functional insights into CARDs of zebrafish (Danio rerio) NOD1 and NOD2, and their interaction with adaptor protein RIP2

J Maharana, B Dehury, JR Sahoo, I Jena, A Bej… - Molecular …, 2015 - pubs.rsc.org
Nucleotide-binding and oligomerization domain-containing protein 1 (NOD1) and NOD2 are
cytosolic pattern-recognition receptors (PRRs) composed of an N-terminal caspase …

B cell activating factor is induced by toll-like receptor and NOD-like receptor-ligands and plays critical role in IgM synthesis in Labeo rohita

M Basu, SS Lenka, M Paichha, B Patel, R Banerjee… - Molecular …, 2016 - Elsevier
B-cell activating factor (BAFF), an important member of the tumor necrosis factor superfamily,
plays critical roles in the modulation of B-cell functions and enhancement of immune …