Asprosin: a novel player in metabolic diseases

M Yuan, W Li, Y Zhu, B Yu, J Wu - Frontiers in endocrinology, 2020 - frontiersin.org
Asprosin, a novel glucogenic adipokine, is encoded by two exons (exon 65 and exon 66) of
the gene Fibrillin 1 (FBN1) and mainly synthesized and released by white adipose tissue …

Asprosin in health and disease, a new glucose sensor with central and peripheral metabolic effects

M Farrag, D Ait Eldjoudi… - Frontiers in …, 2023 - frontiersin.org
Adipose tissue malfunction leads to altered adipokine secretion which might consequently
contribute to an array of metabolic diseases spectrum including obesity, diabetes mellitus …

Increased serum level and impaired response to glucose fluctuation of asprosin is associated with type 2 diabetes mellitus

X Zhang, H Jiang, X Ma, H Wu - Journal of diabetes …, 2020 - Wiley Online Library
Abstract Aims/Introduction Asprosin is a novel secreted adipokine that is induced by fasting
and promotes hepatic glucose release. In healthy humans, circulating asprosin shows …

Serum asprosin concentrations are increased and associated with insulin resistance in children with obesity

M Wang, C Yin, L Wang, Y Liu, H Li, M Li, X Yi… - Annals of nutrition and …, 2020 - karger.com
Objective: Asprosin, a novel peptide that has recently discovered as an important regulatory
adipokine, is relevant to obesity in animals and adult humans. Little is known about its roles …

Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence

K Shabir, JE Brown, I Afzal, S Gharanei… - Cytokine & Growth …, 2021 - Elsevier
White adipose tissue is a dynamic endocrine organ that releases an array of adipokines,
which play a key role in regulating metabolic homeostasis and multiple other physiological …

The roles and associated mechanisms of adipokines in development of metabolic syndrome

JE Kim, JS Kim, MJ Jo, E Cho, SY Ahn, YJ Kwon, GJ Ko - Molecules, 2022 - mdpi.com
Metabolic syndrome is a cluster of metabolic indicators that increase the risk of diabetes and
cardiovascular diseases. Visceral obesity and factors derived from altered adipose tissue …

Decreased circulating levels of asprosin in obese children

W Long, X Xie, C Du, Y Zhao, C Zhang… - Hormone research in …, 2019 - karger.com
Background: Circulating asprosin is a newly discovered adipokine that triggers the release
of hepatic glucose stores and increases appetite. Asprosin levels are elevated in adult …

Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight …

Hİ Ceylan, Ö Saygın, Ü Özel Türkcü - Chronobiology International, 2020 - Taylor & Francis
The aim of this study was to examine the acute effect of aerobic exercise when performed in
the morning and evening on obesity-related hormones of asprosin, spexin, lipocalin-2, and …

Asprosin—a fasting-induced, glucogenic, and orexigenic adipokine as a new promising player. Will it be a new factor in the treatment of obesity, diabetes, or infertility …

AI Mazur-Bialy - Nutrients, 2021 - mdpi.com
Asprosin is a recently discovered protein released during fasting conditions mainly by
adipocytes from white adipose tissue. As a glucogenic peptide, it stimulates the release of …

Asprosin exerts pro-inflammatory effects in THP-1 macrophages mediated via the toll-like receptor 4 (TLR4) pathway

K Shabir, S Gharanei, S Orton, V Patel… - International Journal of …, 2022 - mdpi.com
Adipose tissue is a dynamic endocrine organ, secreting a plethora of adipokines which play
a key role in regulating metabolic homeostasis and other physiological processes. An …