Eukaryotic transcription generally occurs in bursts of activity lasting minutes to hours;
however, state-of-the-art measurements have revealed that many of the molecular …

The eukaryotic transcription cycle consists of three main steps: initiation, elongation, and
cleavage of the nascent RNA transcript. Although each of these steps can be regulated as …

The mRNA life cycle is a complex biochemical process, involving transcription initiation,
elongation, termination, splicing, and degradation. Each of these molecular events is …

An increasing number of studies have shown the key role that RNA polymerase II (RNA Pol
II) elongation plays in gene regulation. We systematically examine how various enhancers …

Recent advances in fluorescence microscopy have made it possible to measure the
fluctuations of nascent (actively transcribed) RNA. These closely reflect transcription kinetics …

Cell-to-cell variability within a clonal population, also known as non-genetic heterogeneity,
has created significant challenges for intervening with diseases such as cancer. While non …

We consider a stochastic model where a gene switches between two states, an mRNA
transcript is released in the active state, and subsequently it undergoes an arbitrary number …

In metazoans, both transcription initiation and the escape of RNA polymerase (RNAP) from
promoter-proximal pausing are key rate-limiting steps in gene expression. These processes …

The genomic revolution has indubitably brought about a paradigm shift in the field of
molecular biology, wherein we can sequence, write and re-write genomes. In spite of …

Gene expression inherently gives rise to stochastic variation (“noise”) in the production of
gene products. Minimizing noise is crucial for ensuring reliable cellular functions. However …