Prostate cancer is the second-leading cause of cancer-related mortality in men in Western
societies. Androgen receptor (AR) signaling is a critical survival pathway for prostate cancer …

Most prostate cancers are androgen-sensitive malignancies whose growths depend on the
transcriptional activity of the androgen receptor (AR). In the 1940s, Charles Huggins …

Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also
castration-resistant prostate cancer (CRPC) is dependent on functional AR and several …

The normal prostate and early-stage prostate cancers depend on androgens for growth and
survival, and androgen ablation therapy causes them to regress. Cancers that are not cured …

The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

Using microarray-based profiling of isogenic prostate cancer xenograft models, we found
that a modest increase in androgen receptor mRNA was the only change consistently …

Androgen receptor (AR) signaling is a key driver of prostate cancer (PC). While androgen-
deprivation therapy is transiently effective in advanced disease, tumors often progress to a …

Prostate-specific antigen (PSA) is an androgen-regulated serine protease produced by both
prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum …

Androgen receptor (AR) plays a central role in prostate cancer, and most patients respond to
androgen deprivation therapies, but they invariably relapse with a more aggressive prostate …

The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in
prostate cancer (PCa) to drive tumor growth, and the AR also can acquire new growth …