Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Gliomas are the most common malignant primary brain tumors, of which glioblastoma is the
most malignant form (WHO grade IV), and notorious for treatment resistance. Over the last …

Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …

Background The CATNON trial investigated the addition of concurrent, adjuvant, and both
current and adjuvant temozolomide to radiotherapy in adults with newly diagnosed 1p/19q …

Background Bevacizumab is approved for the treatment of patients with progressive
glioblastoma on the basis of uncontrolled data. Data from a phase 2 trial suggested that the …

Recently, we described a machine learning approach for classification of central nervous
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …

Aim: To develop a web tool for survival analysis based on CpG methylation patterns.
Materials & methods: We utilized methylome data from 'The Cancer Genome Atlas' and used …

Chemoresistance has been a significant problem affecting the efficacy of drugs targeting
tumors for decades. MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA …

PURPOSE NRG Oncology/RTOG 9802 (ClinicalTrials. gov Identifier: NCT00003375) is a
practice-changing study for patients with WHO low-grade glioma (LGG, grade II), as it was …

We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …