Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …

Molecular oxygen is one of the most important variables in modern cell culture systems.
Fluctuations in its concentration can affect cell growth, differentiation, signaling, and free …

Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …

Engineering cardiac tissues and organ models remains a great challenge due to the
hierarchical structure of the native myocardium. The need of integrating blood vessels brings …

Drug discovery and development are hampered by high failure rates attributed to the
reliance on non-human animal models employed during safety and efficacy testing. A …

Sacrificial templates for patterning perfusable vascular networks in engineered tissues have
been constrained in architectural complexity, owing to the limitations of extrusion-based 3D …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

This paper describes a method for fabricating perfusable vascular channels coated with
endothelial cells within a cultured skin-equivalent by fixing it to a culture device connected to …

We demonstrate here a cardiac tissue-engineering strategy addressing multicellular
organization, integration into host myocardium, and directional cues to reconstruct the …

Tissue engineering is currently limited by the inability to adequately vascularize tissues in
vitro or in vivo. Issues of nutrient perfusion and mass transport limitations, especially oxygen …