Prolonged periods of skeletal muscle inactivity or mechanical unloading (bed rest, hindlimb
unloading, immobilization, spaceflight and reduced step) can result in a significant loss of …

Loss of skeletal muscle mass occurs frequently in clinical settings in response to joint
immobilization and bed rest, and is induced by a combination of unloading and inactivity …

Prolonged skeletal muscle inactivity (eg limb immobilization, bed rest, mechanical
ventilation, spinal cord injury, etc.) results in muscle atrophy that manifests into a decreased …

Key points Five days of bed rest resulted in a reduction in leg lean mass and strength in
older adults. After bed rest, older (but not younger) adults had reduced amino acid‐induced …

The ribosome is a supramolecular ribonucleoprotein complex that functions at the heart of
the translation machinery to convert mRNA into protein. Ribosome biogenesis is the primary …

Skeletal muscles comprise a substantial portion of whole body mass and are integral for
locomotion and metabolic health. Increasing age is associated with declines in both muscle …

Protein synthesis and degradation are dynamically regulated processes that act in concert to
control the accretion or loss of muscle mass. The present article focuses on the mechanisms …

Amino acid (AA) transporters may act as sensors, as well as carriers, of tissue nutrient
supplies. This review considers recent advances in our understanding of the AA-sensing …

Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …

Using an amalgamation of previously studied “train‐low” paradigms, we tested the effects of
reduced carbohydrate (CHO) but high leucine availability on cell‐signaling responses …